- 1. Introduction
- Molecular Genetics and Personalized Medicine
- Genetic Testing and Molecular Biomarkers :
- Molecular Genetics and Metabolism
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Molecular Genetics and Personalized Medicine
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Genetic Testing and Molecular Biomarkers :
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In this study, we aimed to identify the molecular target genes and detect the key mechanisms of HCC. Methods: All profiles were extracted from the Gene Expression Omnibus database. The identified hub genes were testified for survival curve using the Kaplan—Meier plotter database. Results: Expression profiles had overlapped DEGs.
Molecular Genetics and Metabolism
The majority of the DEGs were enriched in membrane-bounded organelles and intracellular membrane-bounded organelles. These DEGs were significantly enriched in metabolic, protein processing in the endoplasmic reticulum and thyroid cancer pathways. PPI network analysis showed these genes were mostly involved in the pathogenic Escherichia coli infection and the regulation of actin cytoskeleton pathways. Combining these results, we identified 10 key genes involving in the progression of HCC.
Meanwhile, the metabolic pathway, protein processing in the endoplasmic reticulum and the thyroid cancer pathway may play vital roles in the progression of HCC. This work is published and licensed by Dove Medical Press Limited. By accessing the work you hereby accept the Terms.